产品详情
简单介绍：
Anti-E2F6 antibody (110-281) [S6MR] (STJ11101356)
详情介绍：
| Host: | Rabbit |
| Applications: | WB/IP |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-E2F6 (110-281) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S6MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IP 1:500-1:1000 ChIP 1:500-1:1000 CUT&Tag 10⁵ cells/1 Mu g |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | E2F6 |
| Gene ID: | 1876 |
| Uniprot ID: | E2F6_HUMAN |
| Immunogen Region: | 110-281 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-281 of human E2F6 (NP_937987.2) |
| Immunogen Sequence: | LDGIDLVEKKSKNHIRWIGS DLSNFGAVPQQKKLQEELSD LSAMEDALDELIKDCAQQLF ELTDDKENERLAYVTYQDIH SIQAFHEQIVIAVKAPAETR LDVPAPREDSITVHIRSTNG PIDVYLCEVEQGQTSNKRSE GVGTSSSESTHPEGPEEEEN PQQSEELLEVSN |
| Tissue Specificity | Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen. |
| Function | Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. Represses expression of some meiosesis-specific genes, including SLC25A31/ANT4. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase. |
| Protein Name | Transcription Factor E2f6 E2f-6 |
| Database Links | Reactome: R-HSA-69205 Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor E2f6 antibody Anti-E2f-6 antibody Anti-E2F6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
相关信息
![Anti-14-3-3 beta/Theta antibody (1-100) [S1MR] (STJ11103651)](http://y1.yzimgs.com/uploads/465546/2024520-20551366.png?imageView2/2/w/200/h/200)
- 细胞培养玄学-MRC-5细胞 2025-01-07
- Ocean NanoTech定制的详细步骤 2021-10-31
- click chemistry tools数据结果比... 2021-10-31
- LaysanBio代理商相关文献资料2020 2021-10-31
- Abbiotec代理的产品得到重复验证2020 2021-10-31
- zyagen Laboratories代理的产品得到... 2021-06-20
- Toxin Technologies代理商相关文献资... 2021-03-14
- 热烈祝贺榴莲视频色版下载安装生物正式代理biocolor公司试剂产品... 2021-03-14
- 热烈祝贺榴莲视频色版下载安装生物正式代理cytognos公司试剂产品... 2021-03-14
- Gelest代理的产品得到重复验证2020 2021-03-14
