Anti-ELAVL1 antibody (1-100) (STJ116295) STJ116295|产品目录|代理商|上海榴莲视频色版下载安装生物科技有限公司

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产品名称：Anti-ELAVL1 antibody (1-100) (STJ116295)
产品型号：STJ116295
产品厂商：ST john's laboratory
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简单介绍：

Anti-ELAVL1 antibody (1-100) (STJ116295)

详情介绍：

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-HuR/ELAVL1 (1-100) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ELAVL1
Gene ID:	1994
Uniprot ID:	ELAV1_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HuR/ELAVL1 (NP_001410.2).
Immunogen Sequence:	MSNGYEDHMAEDCRGDIGRT NLIVNYLPQNMTQDELRSLF SSIGEVESAKLIRDKVAGHS LGYGFVNYVTAKDAERAINT LNGLRLQSKTIKVSYARPSS

Tissue Specificity	Ubiquitous. Detected in brain, liver, thymus and muscle.
Post Translational Modifications	Phosphorylated by MAPKAPK2. Phosphorylated by PRKCD. Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
Function	RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation. Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUUAGUUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR.
Protein Name	Elav-Like Protein 1 Hu-Antigen R Hur
Database Links	Reactome: R-HSA-450520
Cellular Localisation	Cytoplasm Nucleus Stress Granule P-Body Translocates Into The Cytoplasm Following Phosphorylation By Mapkapk2 Likewise Phosphorylation By Prkcd Promotes Translocations From The Nucleus Into The Cytoplasm Where It Is Associated With Free And Cytoskeleton-Bound Polysomes Localizes To The Stress Granules In The Presence Of Plekhn1
Alternative Antibody Names	Anti-Elav-Like Protein 1 antibody Anti-Hu-Antigen R antibody Anti-Hur antibody Anti-ELAVL1 antibody Anti-HUR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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产品名称：Anti-ELAVL1 antibody (1-100) (STJ116295)