产品详情
简单介绍：
Anti-FLNA antibody (C-Term) (STJ110205)
详情介绍：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-FLNA (C-Term) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FLNA |
| Gene ID: | 2316 |
| Uniprot ID: | FLNA_HUMAN |
| Immunogen Region: | C-Term |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2500 to the C-terminus of human Filamin A (NP_001104026.1). |
| Immunogen Sequence: | KYGGPYHIGGSPFKAKVTGP RLVSNHSLHETSSVFVDSLT KATCAPQHGAPGPGPADASK VVAKGLGLSKAYVGQKSSFT VDCSKAGNNMLLVGVHGPRT PCEEILVKHVGSRLYSVSYL LKDKGEYTLVVKWGDEHIPG SPYRVVVP |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylation at Ser-2152 is negatively regulated by the autoinhibited conformation of filamin repeats 19-21. Ligand binding induces a conformational switch triggering phosphorylation at Ser-2152 by PKA. Phosphorylation extent changes in response to cell activation. Polyubiquitination in the CH1 domain by a SCF-like complex containing ASB2 leads to proteasomal degradation. Prior dissociation from actin may be required to expose the target lysines. Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome. |
| Function | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance. During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons. |
| Protein Name | Filamin-A Fln-A Actin-Binding Protein 280 Abp-280 Alpha-Filamin Endothelial Actin-Binding Protein Filamin-1 Non-Muscle Filamin |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-430116 Reactome: R-HSA-446353 Reactome: R-HSA-5627123 Reactome: R-HSA-8983711 |
| Cellular Localisation | Cytoplasm Cell Cortex Cytoskeleton Perikaryon Cell Projection Growth Cone Colocalizes With Cpmr1 In The Central Region Of Drg Neuron Growth Cone Following Sema3a Stimulation Of Drg Neurons Colocalizes With F-Actin |
| Alternative Antibody Names | Anti-Filamin-A antibody Anti-Fln-A antibody Anti-Actin-Binding Protein 280 antibody Anti-Abp-280 antibody Anti-Alpha-Filamin antibody Anti-Endothelial Actin-Binding Protein antibody Anti-Filamin-1 antibody Anti-Non-Muscle Filamin antibody Anti-FLNA antibody Anti-FLN antibody Anti-FLN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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